Manning threw a 20-yard touchdown pass to Anthony Gonzalez with 4:49 remaining for the Colts' first offensive touchdown of the game, and Indianapolis rallied to beat the Oakland Raiders 21-14 Sunday and clinch a first-round bye in the AFC playoffs.

The Colts (12-2) trailed 14-13 after Justin Fargas' 2-yard run early in the fourth quarter. But Manning completed all seven passes on the ensuing drive, including a key third-down conversion to Reggie Wayne, to drive Indianapolis 91 yards for the go-ahead score. Joseph Addai ran in the 2-point conversion to make it a seven-point game.

Kelvin Hayden broke up a fourth-down pass to Jerry Porter from the Indianapolis 16 with 1:50 remaining and the Colts ran out the clock to win it.

The win clinched Indianapolis' fifth straight AFC South title, made the Colts the first team ever to post five straight 12-win seasons and gave them the No. 2 seed in the playoffs because Pittsburgh lost 29-22 to Jacksonville earlier in the day.

The Raiders (4-10) are assured of their fifth straight double-digit loss season.

The Raiders held the high-powered Colts offense in check until midway through the fourth quarter as Indianapolis' first 13 points came on T.J. Rushing's 90-yard punt return in the first quarter and two field goals by Adam Vinatieri.

Addai was held to 44 yards on 15 carries by the league's second worst rush defense, and Manning was just 15-for-31 until the go-ahead drive.

But Manning was sharp when it counted, finishing 22-for-39 for 276 yards and the touchdown on the perfectly thrown pass to Gonzalez's back shoulder. Gonzalez, given added responsibility with Marvin Harrison sidelined, showed why the Colts used a first-round pick on him earlier this year with seven catches for 86 yards.

Fargas had 26 carries for 89 yards, giving him 1,009 for the season, but left in the fourth quarter with a banged-up knee. Josh McCown finished 13-for-24 for 94 yards and a touchdown for Oakland, sitting out three series in the third quarter to allow No. 1 overall pick JaMarcus Russell to play.

Russell, making his second cameo appearance of the season, couldn't generate a single first down on his three drives. Chris McFoy dropped a third-down pass on the first drive, Russell threw an incompletion to Porter to end the next drive and Fargas only gained 1 yard on third-and-2 to end the third drive. Russell finished 2-for-5 for 10 yards before turning the game back over to McCown, who immediately drove Oakland to the go-ahead score.

The Colts took a quick 10-0 lead when Vinatieri kicked a 22-yard field goal on the opening drive and Rushing returned a punt 90 yards for his first career score. Indianapolis looked poised to break the game open when Manning appeared to score on a 5-yard scramble on the next drive.

But Raiders coach Lane Kiffin challenged the play and after a replay review the ball was spotted inside the 1. Thomas Howard broke up a pass in the end zone to Ben Utecht to give the Raiders the ball on downs.