Peyton Manning threw three touchdown passes, Joseph Addai and Clifton Dawson ran for TDs, and the Colts scored on six of their first eight possessions in a 38-15 rout of Houston.

In what was likely to be the last significant action for Indy's starters until mid-January when the AFC's No. 2 seed will play in the divisional round of the playoffs, Manning & Co. finished with 458 yards, scored 38 unanswered points and won their sixth in a row.

The Super Bowl MVP was 28-of-35 for 311 yards with a rating of 132.3 before leaving late in the third quarter. Three Indy running backs — Addai, Dawson and Kenton Keith — combined to give the Colts (13-2) their first 100-yard rushing day since Thanksgiving night, and Dallas Clark broke the single-season franchise records for receptions and touchdown catches by a tight end.

Clark caught six passes for 60 yards and two TDs, giving him 57 receptions for 661 yards and 11 TDs this season. Hall-of-Famer John Mackey held the previous records of 55 receptions and nine TDs.

It was ugly for Houston (7-8), which was trying to win a franchise record eighth game.

Sage Rosenfels was 22-of-36 for 233 yards and three interceptions, including one in the Colts' end zone, after opening the game with a 17-yard TD pass to Kevin Walter.

Indy never gave the Texans a chance after the opening possession.

Manning led the Colts on first-half drives of 54, 92, 92 and 26 yards setting up Adam Vinatieri for a short field goal, Addai for a 2-yard TD run, and Clark for TD receptions of 6 and 11 yards to make it 24-7 at halftime.

Dawson scored on a 4-yard run to open the second half, and Manning threw a 27-yard TD pass to Reggie Wayne in the third quarter, prompting coach Tony Dungy to pull most of his starters.