TONIGHT'S MUST-SEE

"Scrubs" season-opener, 8 and 8:30 p.m., ABC. The show moves to ABC, starting with a couple of pretty good episodes. We meet the new chief of medicine, played by Courteney Cox. Beneath a warm exterior, she's wildly unethical. We also meet this year's interns. One can't stop text-messaging, another is a teacher's-pet type, a third has zero knack for comforting patients. Most of this is quite funny, but there's also room for emotion. The second half-hour has good moments with a dying patient; he's played by Glynn Turman, who won a guest-actor Emmy last year as the grieving dad in HBO's "In Treatment."

"The Biggest Loser" opener, 7 p.m., NBC. This edition is filled with extremes. It has the oldest (63) and youngest (18) contestants in its history; it also has its heaviest woman (379 pounds) and man (454). And it has a medical emergency during the first day. These people — plus trainers Jillian Michaels and Bob Harper — are worth rooting for. Still, in stretching to two hours a week, "Loser" gets terribly repetitive.

OF NOTE

"Homeland Security USA" debut, 7 p.m., ABC. This straightforward series bounces between a lot of situations, some non-vital. We see a 20-year-old Swiss woman who has belly-dance equipment, but no work visa; we see a mail shipment of barbecued bats. Some matters are much more serious; people go to extremes — in these cases, unsuccessfully — to smuggle drugs and people across the borders from Mexico and Canada. Done in a no-frills style by producer Arnold Shapiro ("Rescue 911"), this is moderately interesting.

"NCIS," 7 p.m., CBS. The team is investigating a murder in a women's prison. Then the inmates riot, leaving McGee (Sean Murray) trapped inside.

"Jo Koy: Don't Make Him Angry," 8 and 10 p.m., Comedy Central. At first, Koy might seem like just another angry comic; his diatribe against the French is funny, but familiar. Soon, however, sweetness and humor blend when he describes his son and his Filipino grandmother.

"Nip/Tuck" return, 8 p.m., FX. This show continues in a state of hideous overstatement. Tonight, it revisits Colleen Rose's attack on Sean, then views the effects and hands a crisis to Christian.

"The Mentalist," 9 p.m., CBS. A prisoner says he'll offer information about Red John if Patrick Jane (Simon Baker) can prove him innocent. Jane promptly quits his job to focus on the case.

"Law & Order: Special Victims Unit," 9 p.m., NBC. A teenager returns, telling of four years as a sexual slave. One of her sisters embraces her; the other seems suspicious. Digging into it, police find a bigger story.

"10 Items or Less" season-opener, 9 p.m., TBS. The competing grocery store's new manager (Kim Coles) is a New Yorker, ready to crush Leslie's small-town operation. That seems likely at first, when Leslie obsesses over bowling with frozen turkeys.