LOS ANGELES — Manny Ramirez had a chance to make his debut with the Los Angeles Dodgers one of those special games players and fans dream about.

The disgruntled slugger was 2 for 4 last night, one day after being part of a three-way trade that sent him from Boston to Los Angeles.

And in the bottom of the ninth, with the Dodgers down a run, he came up with a runner on and no outs against Brandon Lyon.

The closer got him to hit into a double play and the Diamondbacks hung on for a 2-1 victory.

"That's a storybook ending right there — Manny getting traded here and coming up (representing) the winning run," winning pitcher Randy Johnson said after his first-place Diamondbacks opened a three-game lead over the Dodgers in the NL West. "But Brandon made some quality pitches and got the double play. He's done his job pretty well all year."

After giving up a leadoff single to Russell Martin, Lyon went 2-2 on Ramirez before throwing him a fastball away. The 12-time All-Star hit a grounder to shortstop Stephen Drew for the rally-killer and Jeff Kent popped out to second, giving Lyon his 24th save in 29 attempts.

"I think I was trying to do too much," said Ramirez, who came in 2 for 3 lifetime against Lyon with a home run. "I was just trying to see the ball and hit it. He made a good pitch and got me out, but tomorrow's another day."

Johnson (9-7) won his fifth straight start and climbed within seven wins of 300, allowing an unearned run and five hits over six innings. The five-time Cy Young winner ran his career record at Dodger Stadium to 7-0, striking out six and increasing his career total to 4,723 — second all-time behind Nolan Ryan.

"My mechanics have fallen into place over the last three or four games and I'm able to throw all of my pitches over for strikes now and stay away from the big inning," Johnson said. "Throwing first-pitch strikes, I had some easy innings and it allowed me to stay out there."

The Big Unit was lifted for a pinch-hitter in the seventh, when the Diamondbacks pulled ahead with two runs against reliever Chan Ho Park (4-3).

Tony Clark tied it 1-1 with a leadoff homer to center. Chris Snyder singled and advanced on Chris Burke's sacrifice bunt before Chad Tracy batted for Johnson and walked. Drew followed with an RBI double than landed just inside the right field line.

Dodgers rookie Clayton Kershaw allowed four hits over six scoreless innings. The 20-year-old left-hander was lifted for a pinch-hitter in the sixth, when Los Angeles took a 1-0 lead on Matt Kemp's RBI double.

PIRATES 3, CUBS 0

Jeff Karstens (1-0), acquired last week in a trade with the Yankees, scattered six hits over six innings in his Pittsburgh debut to help snap host Chicago's five-game winning streak.

Jason Michaels had an RBI single in a two-run second, then hit a solo homer off Jason Marquis (6-7) in the sixth.

BREWERS 9, BRAVES 0

Jeff Suppan (6-7) spaced five hits over seven innings, and Mike Cameron and Prince Fielder hit third-inning home runs as visiting Milwaukee beat Atlanta to end a five-game losing streak.

The Brewers opened a six-game trip with their eighth straight road victory after losing five in a row at home, including four to the Cubs.

ROCKIES 5, MARLINS 2

Right-hander Ubaldo Jimenez (8-9) allowed two hits in seven shutout innings with 10 strikeouts to win his fourth straight start as visiting Colorado beat Florida.

Chris Iannetta and Brad Hawpe hit two-run singles for the Rockies. Hawpe had three of Colorado's 13 hits.

NATIONALS 5, REDS 2

Odalis Perez (4-8) won for the fourth time in 20 starts, allowing a run and three hits over 7 1/3 innings to earn his first home win and help Washington end a nine-game losing streak.

Jesus Flores hit a two-run single in the first, and Washington added three in the second.

ASTROS 7, METS 3

Pinch-hitter Mark Loretta hit a tie-breaking grand slam off Aaron Heilman (1-5) in the bottom of the eighth as Houston beat New York for its fifth victory in seven games.

Kazuo Matsui, Brandon Backe and Carlos Lee had solo homers, all leading off innings against Pedro Martinez, who made his first start since July 12, allowing five hits with five strikeouts in five innings.

CARDINALS 6, PHILLIES 3

Ryan Ludwick homered twice and had four hits, and Joe Mather added a three-run shot to lead host St. Louis over Philadelphia.

Ludwick homered off Cole Hamels (9-7) with two outs in the fifth and led off the eighth with a drive off Ryan Madson. It was his third multi-homer game this season and fifth in his career.

GIANTS 3, PADRES 2

Pinch-hitter Eugenio Velez doubled off the wall in right field in the top of the 10th inning to drive in the go-ahead run, lifting San Francisco over San Diego.

Velez drove a 2-2 pitch off closer Trevor Hoffman (1-6) to score Emmanuel Burriss, who blooped a single to center with two outs.