BALTIMORE — Koji Uehara allowed one run over five innings in his major league debut, Nick Markakis went 3-for-3 with a homer and three RBIs, and the Baltimore Orioles beat Chien-Ming Wang and the New York Yankees 7-5 Wednesday night.

Baltimore improved to 2-0 with its second straight win over the Yankees.

Uehara, the first Japanese-born pitcher in Orioles history, gave up five hits and a walk before leaving with a 7-1 lead. Signed to a two-year, $10 million contract in January, Uehara (1-0) dominated the Yankees in much the same fashion he ruled the Japanese League for 10 seasons with the Yomiuri Giants.

The Orioles provided the right-hander with plenty of offensive support, all of it against Wang (0-1). Making his first start since last June after missing the latter half of the season with a foot injury, Wang yielded seven runs and nine hits in 3 2-3 innings.

A two-run homer by Derek Jeter got New York to 7-4 in the ninth, and Mark Teixeira greeted George Sherrill with an RBI double to bring the tying run to the plate. Sherrill then retired Hideki Matsui on a popup to earn his first save.

After losing the first two games of the series by a combined 17-10 score, the Yankees — who own baseball's highest 2009 payroll at $201 million — will turn to newcomer A.J. Burnett on Thursday to avoid a three-game sweep against a team that last year lost 93 games and finished in the AL East cellar.

New York's offseason spending spree has yet to provide the desired results. CC Sabathia ($161 million contract) took the loss in the opener, and Teixeira ($180 million) went 1-for-5 Wednesday and is 1-for-9 in two games.

Although the crowd of 22,856 was less than half the opening-day sellout, most in attendance continued the practice of booing Teixeira during every at-bat because the hometown player spurned the Orioles to sign with New York.

Baltimore sent nine hitters to the plate during a five-run fourth inning that made it 7-1. Gregg Zaun doubled in a run and Cesar Izturis hit an RBI grounder before Adam Jones added a sacrifice fly. Markakis then chased Wang with a two-run homer to right.

It was Wang's shortest start since going 2 2-3 innings against Toronto in August 2007. It was also the first time in nine starts since Sept. 15, 2007, in Boston that Wang lost on the road.

The Orioles used successive doubles by Jones, Markakis and Aubrey Huff to take a 2-0 lead in the first inning. The damage might have been more severe if Huff didn't get caught trying to steal third before Melvin Mora got Baltimore's fourth straight hit, a single off the glove of shortstop Derek Jeter.

The Yankees had a runner in each of the first three innings before finally breaking through in the fourth on a two-out single by Xavier Nady and Cody Ransom's RBI double off the center-field wall.

New York added a run against Matt Albers in the sixth on doubles by Jorge Posada and Robinson Cano.

Notes: In his initial start with Baltimore, LF Felix Pie went 0-for-3 with a walk. ... Matsui went 0-for-3 against countryman Uehara. ... Jones reached base five straight times to open the season before grounding out in the third. ... Wang was 24-5 in his previous 38 starts.