BOSTON — Baseball's oldest ballpark met the sport's newest innovation, and the New York Mets came away with a come-from-behind victory.

Omir Santos' long fly off the top of the Green Monster — initially ruled a double — became the game-winning homer after the first replay review in Fenway Park history last night, and the Mets rallied against Boston closer Jonathan Papelbon for a 3-2 victory.

"That's what the replay is for," Mets manager Jerry Manuel said. "We could have easily gotten out of there without the two runs and could have had a loss."

The "lyric little bandbox" lauded by John Updike as "a compromise between Man's Euclidean determinations and Nature's beguiling irregularities" found a way to account for technology's latest innovation with two outs in the ninth and Boston leading 2-1.

Santos hit the first pitch from Papelbon (0-1) high to left, where third base umpire Paul Nauert lost it in the lights. Nauert ruled it a double, holding the runners at second and third and preserving — temporarily — Boston's lead.

But the umpires conferred and went into the tunnel for the TV replay, which showed that the ball bounced first off the ledge in front of the Monster Seats, then off the top of the 37-foot wall itself and back onto the field. "I felt like I was waiting for an hour after that," Santos said.

But it was just a few minutes before crew chief Joe West came out and signaled for a home run.

"Cut and dry," West told a pool reporter. "We got together as a crew, got the play right, and that was it."

YANKEES 5, PHILLIES 4:

Alex Rodriguez hit a tying, two-run homer off Brad Lidge (0-2) in the ninth inning and Melky Cabrera capped the three-run rally with an RBI single to lead host New York over Philadelphia. Rodriguez smacked a full-count pitch over the short porch in right for his seventh homer. Robinson Cano followed with a single, stole second and scored without a play on Cabrera's single to right-center.

RANGERS 6, ASTROS 3:

Nelson Cruz homered twice and Hank Blalock also connected as Texas beat host Houston to win its second straight in this season's Lone Star series. Scott Feldman (3-0) allowed three runs in 6 2/3 innings and Blalock finished with three hits for the Rangers.

CARDINALS 5, ROYALS 0:

Kyle Lohse threw eight innings of four-hit ball, Nick Stavinoha drove in two runs, Skip Schumaker added his third homer, and host St. Louis shut out Kansas City for the second straight time. Lohse (4-3) struck out six with no walks.

WHITE SOX 4, PIRATES 0:

Clayton Richard struck out a career-high eight over six innings, Alexei Ramirez homered in his second straight game and host Chicago shut out Pittsburgh for second straight day. Richard (1-0) allowed four hits, and the White Sox won for the fourth time in five games.

BRAVES 4, BLUE JAYS 3:

Derek Lowe pitched into the eighth inning and drove in the go-ahead run with one of his two hits, helping host Atlanta send Toronto to its fifth straight loss. Lowe (6-2) allowed two runs and five hits in 7 1/3 innings, and Rafael Soriano struck out pinch-hitter Kevin Millar and retired Marco Scutaro on a flyball to left with the bases loaded to earn his fourth save.

TWINS 6, BREWERS 2:

Joe Mauer had three hits, a homer and two RBIs to help Anthony Swarzak win his major league debut for host Minnesota. Swarzak (1-0) sprinkled five singles over seven shutout innings, walking two and striking out three.

ROCKIES 4, TIGERS 3:

Todd Helton and Chris Iannetta homered to back an efficient performance by Jason Marquis, and Colorado ended host Detroit's seven-game winning streak. Marquis (6-3) allowed three runs on six hits and a walk in 7 2/3 innings to win his second straight start.

ORIOLES 2, NATIONALS 1:

Aubrey Huff drove in the tiebreaking run with a pinch-hit, two-out triple in the seventh inning, and Baltimore beat host Washington. Huff lined a 1-1 fastball off the top of the center-field wall off Ron Villone to score Cesar Izturis from first.

RAYS 10, MARLINS 3:

Evan Longoria run-scoring single broke a 3-all tie in the eighth inning, Jason Bartlett had three RBIs and two hits, and reserve catcher Michel Hernandez drove in two runs as Tampa Bay beat host Florida. The Rays (23-22) won three consecutive games to climb above .500 for the first time since April 13.

INDIANS 7, REDS 6:

Asdrubal Cabrera drove in the tiebreaking run in the eighth inning, overshadowing Joey Votto's remarkable return from a week of medical tests — homers in his first two at-bats — and rallying Cleveland past host Cincinnati. An inner-ear infection left Votto dizzy during a West Coast trip and led to three days of tests to reach the diagnosis.

DIAMONDBACKS 8, ATHLETICS 7, 11 INNINGS:

Stephen Drew singled in the go-ahead run in the top of the 11th and Arizona beat host Oakland to win its season-high fourth straight game. Oakland's Jason Giambi hit his 400th career home run, becoming the 44th player in major league history to reach the mark.

GIANTS 5, MARINERS 1:

Juan Uribe hit a two-out, three-run double in a five-run eighth inning, and Matt Cain (5-1) tossed his first complete game this season as San Francisco beat host Seattle. With two outs and the bases loaded, Uribe lined a 1-0 pitch from Seattle reliever Mark Lowe to the wall in right-center field, scoring all three runners.

PADRES 3, CUBS 1:

Brian Giles drove in two runs for the second straight night and host San Diego beat Chicago to extend its season-high winning streak to eight games. Josh Geer (1-1) allowed five hits in 6 2/3 innings for the win.

DODGERS 5, ANGELS 4, 10 INNINGS:

Juan Pierre drew a walk with the bases loaded from Jose Arredondo (1-1) in the 10th inning, lifting the host Dodgers over the Angels. Pierre, who grounded into a force play with the bases loaded to end the second inning, had come to the plate without an RBI in 97 career at-bats against the Angels.