BLOOMINGTON, Ind. — Terrelle Pryor threw three touchdown passes and rushed for another score, leading No. 9 Ohio State to a 33-14 victory over Indiana on Saturday night.

The Buckeyes (4-1, 2-0 Big Ten) gave up their first points in nine quarters, but ran away with their 16th straight Big Ten road win, one short of tying the conference record.

Indiana (3-2, 0-2) did little right in its second straight loss. The Hoosiers had three turnovers and gave up a safety after a bad snap on a punt, falling to Ohio State for the 15th straight time.

The Buckeyes were nearly flawless. Brandon Saine ran 17 times for 113 yards, a career-high.

The Hoosiers ended Ohio State's scoreless streak early in the second quarter when Ben Chappell hooked up with Tandon Doss on a 7-yard TD pass. They were hoping for a better showing after nearly upsetting Michigan the week before in Ann Arbor.

Instead, Pryor finished 16 of 27 for 159 yards and rushed 16 times for 63 yards. He heaved a late interception with about six minutes to play in the game, up 33-7.

By then, it was only a statistical blip on an excellent performance.

Ohio State took a 10-0 lead midway through the first quarter, courtesy of Pryor's 5-yard TD pass to Duron Carter.

Indiana closed to 10-7 early on Doss' score, but Pryor needed just three plays to answer. He found DeVier Posey for a 23-yard TD pass to make it 17-7, then closed out the first half scoring with an 8-yard TD pass to Zach Boren.

Pryor sealed it with a 1-yard TD run early in the fourth quarter.

Chappell was 20 of 34 for 210 yards with two interceptions and two touchdowns, the second as time ran out.