KANSAS CITY, Mo. — Royals outfielder Jose Guillen will miss the rest of the season because of a right knee injury.

Guillen sat out 37 games with a ligament tear in his knee, but was activated from the disabled list Tuesday. He struck out as a pinch hitter that day and was the starting designated hitter Wednesday, but left after only two at-bats with pain in his right hamstring.

"After reviewing Jose's situation, we are just going to shut him down for the rest of the year and give him an opportunity to get his body as healthy and strong as possible going into spring training next year," Kansas City manager Trey Hillman said Saturday. "He will not be playing any more ballgames this season."

The 33-year-old Guillen is in the second season of a $36 million, three-year contract, making him the highest paid position player in Royals history.

Guillen, who also was on the DL in April with a partial tear of his right hip flexor tendon, appeared in 81 games this year, hitting .242 with nine home runs and 40 RBIs.